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With 476,857 individuals across 18 different countries (propensity score matched 1:1 with pregnant controls), this is the largest study to date in this historically underserved population

As of June 2026, the FDA's December 2024 Pharmacy Compounding Advisory Committee evaluation concluded that the criteria weighed against placing AOD-9604 (free base) or AOD-9604 acetate on the 503A Bulks List, and AOD-9604 is currently listed as Nominated but Withdrawn from FDA Category 2

GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

Bian Y, Dong Y, Sun J, Sun M, Hou Q, Lai Y

These sulfites are usually highly reactive intermediates, which can immediately generate thiosulfite through condensation reaction in the cell (Alinezhad et al., 2013)

doi: 10.1016/j.ygeno.2021.01.022 70 ShuK.LiuX