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Estrogen plays a crucial role in both the development and maintenance of endometriosis

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According to this hypothesis, -synuclein fibrils spread through the axons in a gut-brain orientation, with the dorsal motor nucleus of the vagus nerve (DMV) (Rogers et al., 1980

doi: 10.1172/JCI64516 29 KoikeHIguchiYSahashiKKatsunoM

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Blanco) were derived from E14.5 d embryos, SV40 T-antigen transformed, and grown in Dulbeccos modified Eagles medium (DMEM, Corning) containing 10% fetal bovine serum (VWR Life Sciences, Seradigm) and 100 g/mL penicillin (Sigma) at 37 C and 5% CO 2