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Reuter SE, Evans AM
10.1016/j.molmet.2019.06.026 81
Too much insulin can lead to insulin resistance, decreasing its effectiveness and resulting in high blood sugar
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In summary, these potentially novel Mmut p.L690Ins/p.L690Ins mice recapitulate many of the biochemical and clinical presentations of MMA seen in human patients, survive into adulthood, and can be rescued with gene therapy
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