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A phase I/II study in subjects with advanced or metastatic solid tumors to evaluate the combination of INCB059872 with programmed death receptor-1 (PD-1) inhibitor pembrolizumab and the indoleamine 2,3-dioxygenase (IDO-1) inhibitor epacadostat has also been terminated by sponsor (ClinicalTrials.gov Identifier: NCT02959437)
histamine release by a direct effect on mast cells
By affecting all these cellular functions already impaired in aging individuals it could explain why older, comorbid patients have the most severe outcomes with COVID-19 (312) and stimulate the use of GSH and Nrf2 enhancers as well as develop new therapies to protect mitochondria
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Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M (2013) Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
Ladram A, Besn I, Breton L, et al
