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Tests on a variant called P.1, first identified in Brazil, show that Comirnaty will likely work against it as well

These engineered T cells depend on various metabolic pathways to support their activation, proliferation, and effector functions, which are closely associated with the limited efficacy of CAR-T cells in solid tumors

doi: 10.1038/s41551-021-00766-1 57 Reticker-FlynnNEZhangWBelkJABastoPAEscalanteNKPilarowskiGOWet al

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BCRP transports many hydrophilic conjugated organic anions instead of hydrophobic compounds that are most likely substrates of P-gp