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They required a delivery system that could carry glutathione past the stratum corneum to reach dermal fibroblasts, a feat impossible for standard formulations

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Moreover, amino acid metabolism regulates the redox balance through the generation of nicotinamide adenine dinucleotide phosphate (NADPH) and reduced glutathione (GSH), which are essential for cellular defense against oxidative stressa key driver in IPF progression [7, 19]

340 Therapeutic leverage of ROS elevation in cancer treatment Since the 1950s, various strategies/drug research have been implemented based on this concept, such as administering ROS or ROS-generating enzymes to tumor cell lines or murine models with tumors