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This silent progressive disease, affecting large and mid-sized arteries, with the absence of a luminal elastin barrier and exposure of a dense collagen/proteoglycan, can block blood flow and cause ischemic impairment of downstream tissues or sudden rupture of atherosclerotic plaques (Wolf and Ley, 2019)

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Other metabolites derived from gut microbial metabolism include indole derivatives, imidazole propionate (ImP), and succinate, which have been linked to risks of adverse cardiovascular events

This is clearly not the case, as mutants in various aging pathways differentially alter overall fat storage
