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Notably, in certain cellular contexts, NF-B appears to be essential for mediating the apoptotic effects initiated by P53 (60), highlighting the intricate and context-dependent nature of the interplay between these two signaling pathways

Zinc is physiologically interconnected with copper, and excess zinc is usually associated with disrupted copper homeostasis (Maret and Sandstead, 2006[290])

It can also be associated with gliosis in the affected area or alter the integrity of the blood-brain barrier resulting in inflammatory events and altered tissue vascularization (Stephenson et al., 2014)
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