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To identify specific interactors, even those in low abundance while eliminating abundant contaminant proteins, cell lines stably expressing the LAP-tag-containing wild-type FUS/TLS were grown in isotopically heavy medium containing 13 C 6 , 15 N 4 -arginine and 13 C 6 , 15 N 2 -lysine, while the parental line (that is, no transgene) was grown in light medium containing normal arginine and lysine (Fig

Interaction between glutathione and apoptosis A decrease in cellular GSH concentration has long been reported to be an early event in the apoptotic cascade induced by death receptor activation [5], mitochondrial apoptotic signaling [110], and oxidative stress [62,111]

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The combination of low intracellular GSH levels and low expression of ABCC1 and ABCC2 in proliferative endothelial cells accounts for GSAO selectivity and subsequently for GSAO anti-angiogenic properties (Dilda et al., 2005a,b