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This reduces the chance of irritation and potential interactions

Ranjekar PK, Hinge A, Hegde MV, Ghate M, Kale A, et al
Toxicity induced by multiple high doses of vitamin B(12) during pernicious anemia treatment: a case report

& Melton, L

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The 177191 fragment was identified as the lipolytic active site, and a tyrosine residue was added at the N-terminus to enhance stability
