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doi: 10.1136/bmj.a386

Studies have shown that through direct ionization or indirect effects mediated by reactive oxygen species (ROS), IR causes DNA damage, protein modification, and lipid peroxidation in LECs, leading to cell apoptosis or necrosis and lens opacity ( In recent years, ferroptosis, as a new form of cell death, has gained widespread attention for its role in various diseases such as neurodegenerative disorders, ischemiareperfusion injury, and cancer ( Although the crucial role of ferroptosis in various diseases has been widely recognized, its role in ionizing radiation-induced lens damage remains unclear