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Significantly decreased insulin and insulin receptor expression was observed in postmortem AD brain tissue, and changes in downstream insulin signaling molecules, including decreased levels of IRS-1/2, PI3K, p-Akt (51, 54)

If nausea is severe or accompanied by persistent vomiting, abdominal pain, or signs of dehydration, seek medical advice promptly as these may indicate serious complications
It is typical that the weight returns within two years unless the changes endure past the medication period
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