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Why does hydroquinone cause rebound hyperpigmentation when you stop using it? Hydroquinone destroys tyrosinase irreversibly by denaturing the enzymes copper active site, which triggers melanocytes to upregulate MITF (microphthalmia-associated transcription factor) the master regulator of melanocyte activity as a compensatory response

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As I lost a fair bit of blood from my injuries and didn't have any transfusions he thinks I may be anemic which the restless legs seem to confirm

Front Endocrinol (Lausanne) 11:554994

multiple t-tests)

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