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BDNF signaling is known to regulate ARC expression through the ARC SARE site located ~7.7 kb upstream of the transcription start site 22,23 and is regulated by enzymes involved in epigenetic modulation 22,23 , and therefore we examined if there were epigenetic changes at this location (Fig

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Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

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J Biotechnol 322:6673

R., Sciurba F