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Figure 4 Discussion ASDs are among the most heritable neuropsychiatric conditions, with early epidemiological studies estimating concordance rates of ~90% in monozygotic twins, compared to ~10% for dizygotic twins (Steffenburg et al., 1989

doi: 10.1038/onc.2015.60

Furthermore, biomarker-driven patient stratification should be integrated into clinical trial designs to identify patients most likely to benefit from CSC-directed therapies

This has been used for the treatment of Kawasaki disease, which was reported as early as in 1950

In a study with a SARS-CoV-2-infected rhesus macaque, arginine supplementation to isolated peripheral blood mononuclear cells inhibited the release of pro-inflammatory cytokines, including IL-6 and TNF- [208]

Clinical manifestations include acute pain crises, hemolytic anemia, and multi-organ dysfunction, imposing substantial morbidity and mortality challenges