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Mechanistic ambiguity compounds these issues: most NPs lack fully defined targets (Wang et al., 2022a), and their polypharmacology, though potentially advantageous for multifactorial diseases like IPF, risks off-target effects (Meng et al., 2018)

& Saper, C

58 While liver biopsy can be helpful in providing supportive findings, it is not required to diagnose PFIC2, as genetic testing remains the gold standard

doi: 10.3181/00379727-210-43939a

Hypoxia Induces miR-153 through the IRE1-XBP1 Pathway to fine Tune the HIF1/VEGFA axis in Breast Cancer Angiogenesis

A significant outcome of the inflammatory pathology linked to cytotoxicity and hypoxia within the tumor microenvironment is an increase in local tissue lactate levels [17]