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For many research protocols, particularly those involving long-term observations or where ease of administration is a significant factor, an oral compound is often the first choice

Since cysteine is known to be neurotoxic in excessive amounts [32], treatment with N-acetylcysteine should not be recommended for patients with glutathione synthetase deficiency as this may increase the intracellular cysteine levels even more

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Vitamin B-12 is a water-soluble B complex vitamin that is present naturally in a variety of food sources such as fish, meat, and dairy products

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Our benchmarking did not explicitly address non-CpG methylation nor DNA methylation variants (5hmC, 5fC and 5caC), but most of the included assays can be used to measure non-CpG methylation as well as CpG methylation, and they can also be adapted to distinguish between DNA methylation variants 61,62,63