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Key takeaways include the dose-dependent neurotoxicity of ethanol, the vulnerability of developing brains to persistent affective changes, and the interplay between genetic susceptibility and environmental stressors in shaping clinical outcomes

Retrieved April 10, 2023

Is that going to impact efficacy

A specific type of autophagy mediated through the nuclear receptor co-activator 4 (NCOA4, a cargo receptor) called ferritin autophagy degrades ferritin, which in turn increases the size of the unstable iron pool in the cytoplasm to induce ferroptosis (18)

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