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It binds to HGF with high affinity (Kd = 65 pM) and markedly augments the capacity of HGF to activate c-Met phosphorylation, even at subthreshold concentrations of the growth factor

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10.1016/S0140-6736(23)01301-6 38 GengY.FaberK

We dont prescribe Accutane to individuals who are unwilling or unable to guard against pregnancy and are people of childbearing age, as isotretinoin can cause severe birth defects