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When the NAM level increases, the enzymatic activity of NNMT (Km = 430 M) is upregulated to clear excess NAM and remove the inhibition effect of NAM on PARPs, sirtuins, or others

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Radioligand therapy Among the various therapeutic strategies, radioligand therapy (RLT) stands out as a promising approach that offers precise targeting of malignant cells while minimizing exposure to healthy tissue

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