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However, an intervention study clearly demonstrates the lack of influence of an increase in serum UA on the progression of established PD

Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy

Additionally, ROS upregulation of HIF-1 can increase angiopoietin-like 4 expression in osteoclasts and enhance osteoclast activity (228, 229)

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Together, these findings underscore receptor-targeted modulation as an effective strategy for expanding the therapeutic scope of PRLM-based interventions

Furthermore, lipid peroxidation enhances the capability of radiotherapy and chemotherapy by increasing the level of oxidative stress in cancer cells where the balance shifts toward cell death