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[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR

The same study observed that, in human neuroectodermal cells, folate deficiency was associated with the disrupted recruitment of histones and DNA repair machinery to the required neural tube closure genes, leading to the accumulation of rare genetic variants during neural tube closure, which contributed to the onset of NTDs [258]

Although Bayesian fine-mapping can provide valuable insights, the modest sample sizes and limited number of genome-wide significant variants in some ancestry groups prevented generation of informative credible sets, and thus fine-mapping was not feasible in the current study

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