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Zimmermann MB, Aeberli I

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Role of TGF- 1 Several studies have demonstrated that mechanical stretch can activate latent TGF- 1 present in the ECM and that this process is inhibited by antagonizing integrins and independent from protease activity, thus establishing a link between the mechanical force of vein wall stretch and activation of the biological molecule, TGF- 1 [117120]

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Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, et al

Upon cellular entry, copper is frequently bound initially by GSH, which functions as a buffering and trafficking intermediate before transferring the metal to MTs for storage or delivery to cuproenzymes