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Together with NHR-80, NHR-49 functions in neurons to prolong lifespan upon activation by PKA signaling from muscle tissue (Schmeisser et al., 2019)

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2019) Mouse cardiac fibroblasts treated with TMAO also exhibited increased NLRP3 inflammasome activation, while silencing RNA (siRNA)-mediated knockdown of NLRP3 in cardiac fibroblasts blunted TMAO-induced cell proliferation as well as TGF- and collagen expression

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10.1016/j.lfs.2024.123304 22 LawtonM

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Timing of onset of adverse events with setmelanotide, an MC4R agonist, in patients with severe obesity due to LEPR or POMC deficiency

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