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Trx1(SH) 2 catalyzes denitrosylation of caspase3 nitrosylated at Cys163, whereas Trx1SNO prevents apoptosis by transnitrosylating caspase3 at the same cysteine residue and induces oncogenic cell transformation [134, 136-138]

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[DOI] [PubMed] [Google Scholar] 233.Volodina DE, Gureev AP, Shaforostova EA, Gryaznova MV, Ignatyeva DA, Popov VN

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While it can be nothing more than speculation because of the small sample size, patients who showed therapeutic effects following glutathione treatment appeared to be younger and did not have diabetes or had mild diabetes

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