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Nucleoside-analog reverse transcriptase inhibitors such as adefovir dipivoxil are well known for their mitochondrial toxicity and may be involved in HIV-associated neurodegeneration and other accelerated aging phenotypes ( Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors

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Penn D, Zhang L, Bobrowski PJ, Quinn M, McDonough KH: Carnitine deprivation adversely affects cardiac performance in the lipopolysaccharide- and hypoxia/reoxygenation-stressed piglet heart

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