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185 In an uncontrolled trial that included 52 men with infertility deemed not surgically treatable, 50 mg of saffron three times weekly for three months led to improvements in sperm motility and morphology, but not sperm counts

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These events trigger downstream signaling pathways, including AKT, Ras (rat sarcoma), and STAT3 pathways, which are required for MET biological activities (Ponzetto et al., 1994