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Just how much of a challenge this posed can be gauged from the fact that Mutt's group needed 10km of porcine small intestine to obtain about 1mg of pure secretin (Rehfeld 2012)
This interval aligns with recommendations from the Bone Health and Osteoporosis Foundation (BHOF) and allows sufficient time to detect clinically meaningful changes in bone density while enabling timely intervention if significant loss is identified
doi:10.3390/medicina60030357 Hellstrm PM, Nslund E, Edholm T, et al
But theres a lot still to learn, but its a really fascinating space, for sure
The shortage rule To understand why compounding pharmacists can make copies of semaglutide (the key ingredient in Ozempic and Wegovy) and tirzepatide (the key ingredient in Mounjaro and Zepbound), you have to understand the shortage rule
Gerstein HC, Colhoun HM, Dagenais GR, for the REWIND Investigators, et al
