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These circumstances can make the situation very difficult to manage

Use of the drugs in sedentary rats had more detrimental effects on testes

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To avoid these undesired cellular destructions, organisms have evolved the glutathione-dependent glyoxalase pathway 3 and NAD(P)H-dependent Aldo-Keto reductase pathway 11

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This reduced binding may affect its bioavailability and interactions with target tissues in experimental models