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Even though the production of ATP (or GTP, based on the subunit composition of succinate-CoA ligase) through mtSLP is minor compared to the output from mitochondrial F 0 -F 1 ATP synthase, its synthesis within the much smaller mitochondrial matrix -roughly one to two orders of magnitude smaller volume than the cytosol 233,234,235 -results in a proportionally greater increase in ATP (or GTP) concentration

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The virus-induced HMRD results in 5 possible infectious outcomes: asymptomatic, mild, moderate, severe to fatal episodes