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Bynigeri RR, Malireddi RKS, Mall R, Connelly JP, Pruett-Miller SM, Kanneganti TD
Key regulators such as AKR1B1 (aldose reductase isoform), GSK-3 (glycogen synthase kinase 3), TNF-, and IFN- are central to the inflammatory and metabolic dysregulation seen in this condition, yet their modulation by HS has not gained traction

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Basnet H, Tian L, Ganesh K, Huang YH, Macalinao DG, Brogi E, Finley LW, Massague J

Why this happens has been a mystery for more than three decades, ever since Jeffrey M
