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L., Olson, R

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Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants

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127,128 Activation of these kinases leads to the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2), which reduces global protein synthesis while selectively enhancing the translation of stress-related transcription factors like ATF4, ATF5, and CHOP, thereby activating the mt-UPR