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In addition, some inducers of these enzymes affect phase I detoxification enzymes, which frequently may transform procarcinogens to actual carcinogens via metabolic activation by hydroxylases such as cytochrome P450

[9] Because liver fat in MASLD is fundamentally a downstream consequence of positive energy balance and insulin resistance, any intervention that drives large, sustained weight loss is a plausible candidate for reducing hepatic steatosis which is the central hypothesis this article evaluates

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