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In the phase 3 randomized, double-blind, multicenter, placebo-controlled REDEFINE 1 and REDEFINE 2 clinical trials, conducted over 68 weeks, CagriSema (Novo Nordisk)a once-weekly combination therapy of the weight-loss medications semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, and cagrilintide, an amylin analogdemonstrated significant weight loss and metabolic improvements compared with placebo
Hypoxia-inducible factor 1 and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer
