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2.2.2 Endoplasmic reticulum: regulator of lipid metabolism and redox homeostasis The ER maintains cellular homeostasis through protein synthesis, lipid metabolism, and calcium storage ( - localized to the ER membranemediates cystine import for GSH synthesis (66)

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The R -gene mediated, hypersensitive-type resistance (HR, incompatible interaction) is based on a specific interaction, either directly or indirectly, of a bacterial effector gene product with the R gene of the host plant

There is evidence that the monomeric (non-aggregated) and oligomeric (a few grouped together) but still soluble forms of huntingtin, and smaller fragments that can come from proteolytic cleavage are especially toxic to cells while larger, insoluble inclusion bodies might be more protective