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It is interesting to observe that ergothioneine is found in high amounts in certain plants, mushrooms and spirulina, that have been used and investigated for their medicinal properties (14,22,23)

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Consistently, an increasing number of well-designed human studies indicated that adjuvant supplementation with specific probiotics can improve the efficacy of vaccines against influenza, cholera, and various childhood diseases ( These observations are supported by a systematic review of clinical trials, which found that probiotics can positively modulate vaccine-induced immune responses (513)