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When metallic NPs derived from plant extracts are used as antidiabetic agents, their distinct properties contribute to their efficacy through multiple mechanisms

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doi: 10.1001/archopht.116.12.1629, 199
they work by binding bile acids in the intestine so theyre carried out in stool instead of being reabsorbed.48 Some aluminum-based antacids (like aluminum hydroxide) can bind bile acids, too.49 Because these products trap bile acids in the gut, they can trap TUDCA as well reducing its absorption and likely blunting any effect