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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

Research indicates certain peptides support sperm count, motility, and hormonal balance

Luki, M., Panteli, I., & Savi, S

How Do Peptides Stimulate Hair Growth

Parietal cells in the stomach produce a glycoprotein called intrinsic factor, which is necessary to absorb vitamin B12 in the terminal ileum

Using non-human models, they showed clearly that vitamin B12 and folate reduced liver inflammation and liver scarring (fibrosis) in NASH