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Other sources of ROS include cytochrome P450, xanthine oxidase (XO), peroxidases, the endoplasmic reticulum, cyclooxygenases, and uncoupled nitric oxide (NO) synthase (de Almeida et al

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However, educated by environmental signals in the TME, macrophages can acquire a M2-like phenotype and transform into tumor-associated macrophages (TAMs), which are known to facilitate tumor progression 18,19,20

Overall, supplementation with CoQ10 has some evidence of efficacy

The particle size of the nanoparticles obtained was not uniform, 40-150 nm