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M.KursanS.PachecoR.Dias-JuniorE.CastropH.et al (2019)

These metabolic networks not only form cross-regulatory feedback loops with inflammatory signaling, contributing to disease pathogenesis and progression, but also enable immune phenotype reprogramming via targeting metabolic enzymes, thus offering novel therapeutic strategies for cancer immunity, tissue repair, and immune-related diseases

It remains classified as an investigational peptide rather than an approved medicine

The scientific picture, however, is far more complicated, and far more cautious

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis