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16 A further meta-analysis indicated that high plasma TMAO concentrations in chronic heart patients increased the risk of MACEs by 58%, and this increase was higher (96%) in patients with longer follow-up (4 years)

Siekmeier R, Scheuch G

The most reliable data comes from a 2020 systematic review and meta-analysis of 37 randomized controlled trials (about 2,300 participants)

Therapeutic strategies for early atherosclerosis mostly revolve around the reduction of lipids levels

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