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Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms

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The crucial function of B12 in sleep latency is reinforced by a previous study that examined the impact of vitamin B12 supplementation on the sleepwake cycle of individuals with delayed sleep phase syndrome, showing a significant temporary improvement in the supplemented group [26]

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