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Size does not determine alone the fate of nanocarriers, the same permeability values were measured for polystyrene nanoparticles with 100, 200 or 400 nm diameter across a microfluidic BBB model [59]

Poor oral bioavailability is one of the greatest obstacles: curcumin is quickly eliminated in the liver and intestines to glucuronide and sulfate conjugates, which leads to low systemic exposure, short plasma half-life and low tissue penetration [12]

[DOI] [PubMed] [Google Scholar] Little C

Thus, the number of studies that attempted to find a relationship between intake of a specific nutrient and a form of cataract is mentioned, but null data are not fully described in the text, and supplementary figures were kept to a minimum by excluding figures for nutrients for which only null data were obtained

That choice is what keeps the release pulsatile and physiologic instead of a flat, all-day elevation

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