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Around 1 in 6 people are living with fertility issues
Another severe NLS mutation (P525L) provided modestly better rescue of splicing changes, but was still far less efficient than wild-type FUS/TLS
10.1016/j.placenta.2015.06.010 33
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Additionally, pirin (PRI), an iron-binding nuclear protein, plays a critical role in nuclear stress during ferroptosis by downregulating ACSL4 mRNA and its product, AA, thereby inhibiting ACSL4-mediated ferroptosis in PDAC [44]
