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The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

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Though some natural therapies may someday be proven as effective as drugs, ophthalmologists should be prepared to explain to patients the principles of evidence-based medicine, so that patients are less likely to waste time and money on snake oil