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Folate is needed for cell growth, especially fast-dividing cancer cells, and the decrease in folate with MTHFR variants can protect against growth in fast-growing tumors

Within the gut UDCA bids to and activates the bile acid receptor, G-protein coupled bile acid receptor 1, GPBAR1 (originally identified as TGR5 and also known as GPR131) to enhance the expression of the proglucagon (GCG) gene in enteroendocrine L-cells resulting in increased production and release of GLP-1

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Homozygous UGT1A1*28 causes Gilbert syndrome , a benign condition affecting 5-10% of the population characterized by intermittent unconjugated hyperbilirubinemia (elevated indirect bilirubin) triggered by fasting, stress, illness, or menstruation

efflux of the drug from cells has not been characterized, although the time course of pentostatin's effects (eg, adenosine deaminase inhibition) varies among different types of cells (eg, lymphocytes, erythrocytes)

GSH content also varies among different areas of the same tissues