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Description
TP53 is recognized to mediate its tumor-suppressive functions by adjusting the expression of genes that promote cell cycle arrest, apoptosis, and senescence (156)

However, their modest efficacy in slowing GA lesion growth without demonstrating clear functional benefit, the burden of monthly or bi-monthly intravitreal injections, and potential safety concerns, including an increased risk of conversion to neovascular AMD, have limited their clinical use and precluded regulatory approval in Europe

doi: 10.3389/fpls.2017.00710

These amino acids join the protein in order and are connected by a condensation (dehydration synthesis) reaction

[Abstract]2024 May 16;43(5):114249

[92] found that CCH caused dramatic inhibition of LTP formation in the hippocampus and luteolin was able to prevent the LTP impairment
