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J Hepatol

After systemic administration, they engage both GLP1R and GIPR simultaneously in native tissue, enabling the study of receptor engagement, metabolic responses, and therapeutic effects at the cellular and organ level, going beyond localization to provide functional readouts directly in living models

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Evidence from eight randomized controlled trials (6,361 participants) also suggested that these effects might be maintained for up to 3.5 years, although long-term safety data were limited