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Androstenedione, DHEA, and DHEA-S are produced mainly by the adrenal cortex, and in relatively small quantities, while testosterone is mostly secreted by Leydig cells ( As previously mentioned, androgens play a vital role in the regulation of glucose and lipid metabolism in patients with chronic diseases such as obesity and diabetes, which is mainly achieved by binding to AR ( Inhibition of androgens and/or AR is strongly associated with disorders of glucose and lipid metabolism

doi: 10.1016/j.dci.2024.105230

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Although the underlying molecular mechanism remains obscure, it has been suggested that apo-AV may help direct lipoproteins to the site where hydrolysis occurs [51]