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These complexes all contain the calcitonin receptor (CALCR) as a core protein and either one of three receptor activity-modifying proteins (RAMPs), RAMP1, RAMP2 or RAMP3

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As with other hormones, due to the general age-related decline of neuroendocrine function, levels of GH fall with advancing years, leading to reduced lean muscle mass, increased body fat, thinning skin, decreased bone density, lowered immune and cardiovascular function, even brain aging